Conventional Synthesis of Isonitroso Phenyl 2 Propanone and It’s Screening for Antibacterial and Antifungal Activities

نویسندگان

  • N. V. Saraf
  • R. D. Raut
  • M. D. Choudhary
چکیده

A new ketone Isonitroso phenyl 2 propanone (HINP2P) has been synthesized by the reaction of Benzyl magnesium chloride with cadmium chloride and acetyl chloride. On subsequent treatment of Phenyl 2 propanone with namyl nitrite gives Isonitroso Phenyl 2 Propanone. The structure of these compounds has been confirmed by physiochemical and spectral data. A preliminary screening of these compounds for biological activity against microorganisms has indicated that they are selective growth inhibitors.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities

Abstract: A series of N-[2-(8-metoxy-2H-chromen-2-one)ethyl] piperazinyl quinolones containing a carbonyl related functional groups (oxo or oxyimino) on the ethyl spacer of coumarin and piperazin rings was synthesized and studied for their antibacterial and antifungal activities . The synthesis of compounds (6a-6l) was achieved through the versatile and efficient synthetic route that involved r...

متن کامل

Synthesis and Study of Some New Quinolone Derivatives Containing a 3-acetyl Coumarin for Their Antibacterial and Antifungal Activities

Abstract: A series of N-[2-(8-metoxy-2H-chromen-2-one)ethyl] piperazinyl quinolones containing a carbonyl related functional groups (oxo or oxyimino) on the ethyl spacer of coumarin and piperazin rings was synthesized and studied for their antibacterial and antifungal activities . The synthesis of compounds (6a-6l) was achieved through the versatile and efficient synthetic route that involved r...

متن کامل

سنتز و ارزیابی برون‌تنی اثرات ضد‌قارچی و ضد‌باکتریایی مشتقات 2و3-دی‌هیدروکینازولینونی

 Introduction: By development of bacterial drug-resistance to traditional antibacterial drugs and fungal  infections, the need to design, synthesis, and use of new and effective antibacterial and antifungal drugs is increased. Quinazolinone derivatives are heterocyclic compounds with nitrogen atoms that have pharmacological properties such as anti-bacterial, anti-tumor, anti-inflammatory and an...

متن کامل

Synthesis and Study of Antibacterial and Antifungal Activities of Novel 3-Alkyl-2,6-diarylpiperidin-4-one-2- thienoyl Hydrazone

In the present work a new series of 3-alkyl-2,6-diarylpiperidin-4-one-2-thienoyl hydrazones have synthesized by the reaction of 3-alkyl-2, 6-diarylpiperidin-4-one with 2-thiophenecarboxylic acid hydrazide and characterized by spectral (IR, H NMR, C NMR, HSQC, HMBC, NOESY and COSY) techniques. The hydrazones were screened for their in vitro antibacterial and antifungal activities against some se...

متن کامل

Multicomponent Solvent-Free Synthesis, Antimicrobial and Antifungal Evaluation of Novel N-Amino Benzylthiolates

Novel N-amino benzylthiolates were synthesized via multicomponent reaction of malononitrile, isothiocyanates and benzyl halides under conventional and solvent-free conditions. Various electron-donating and -withdrawing substitutes within both isothiocyanates and benzyl halides were used to demonstrate the efficiency of new methodology. A broad spectrum of antibacterial and antifungal activities...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012